Anomalous reaction of 4-chloro-7-nitrobenzofurazan with thiol compounds
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چکیده
منابع مشابه
Impairment of the catalytic activity of Escherichia coli ribonucleic acid polymerase by a unique reaction of 4-chloro-7-nitrobenzofurazan.
Escherichia coli RNA polymerase loses 55-65% of its catalytic activity on reaction with Nbf-Cl (4-choro-7-nitrobenzofurazan). This partial inactivation was shown to be the result of specific impairment of RNA-chain elongation, since initiation of RNA chains was not altered after treatment with Nbf-Cl. The site of reaction was shown to be a unique thiol on the beta-subunit. This thiol is not acc...
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4-Chloro-7-nitrobenzofurazan reacts by nucleophilic substitution with phenoxide anions derived from estriol (2c), ethynylestradiol (2d), phenol (3e), guaiacol (3f ), 2,6dimethoxyphenol (3g), eugenol (3h), isoeugenol (3i), the cytostatic Etoposide (4), and Reichardt’s betaine (5) in the presence of crown ethers a¬ording the corresponding 4-aryloxy7-nitrobenzofurazan derivatives 6c, 6d, 7e { 7i, ...
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1. Modification of a single amino acid residue by introduction of the nitrobenzofurazan group inactivates mitochondrial ATPase (adenosine triphosphatase) when membrane-bound in submitochondrial particles. The similarity between the reactions of both membrane-bound and isolated ATPase with 4-chloro-7-nitrobenzofurazan indicates that the single essential tryosine residue identified in the isolate...
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Recent studies have indicated that peroxidase might function in the biological synthesis of thyroxine by the thyroid gland. Johnson and Tewkesbury (1) believed that thyroxine might be formed by the oxidative coupling of 2 molecules of diiodotyrosine. Westerfeld and Lowe (2) studied the oxidative condensation of p-cresol by hydrogen peroxide and peroxidase and suggested that peroxidase might be ...
متن کاملReaction of thiol compounds with peroxidase and hydrogen peroxide.
Recent studies have indicated that peroxidase might function in the biological synthesis of thyroxine by the thyroid gland. Johnson and Tewkesbury (1) believed that thyroxine might be formed by the oxidative coupling of 2 molecules of diiodotyrosine. Westerfeld and Lowe (2) studied the oxidative condensation of p-cresol by hydrogen peroxide and peroxidase and suggested that peroxidase might be ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1979
ISSN: 0264-6021
DOI: 10.1042/bj1770385